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National Academies of Sciences, Engineering, and Medicine; Well being and Drugs Division; Board on Well being Care Services; Committee on Making certain Affected person Entry to Inexpensive Drug Therapies; Nass SJ, Madhavan G, Augustine NR, editors. Many different medical situations may also enhance the chance of extreme sickness from COVID-19, together with having a weakened immune system after a stem cell (bone marrow) transplant, or after getting different medicine that weaken the immune system (equivalent to cancer chemotherapy medication).
In Europe, single-payer health techniques and managed entry agreements pushed drugmakers to take part in danger-based mostly or outcomes-based contracts several years in the past, and people practices are being adopted in different geographies, especially for revolutionary specialty drugs and orphan products.
In contrast to the prolonged testing a new drug undergoes, the approval course of to market generics is usually restricted to bioequivalence data from the laboratory, and the outcomes of a trial with a couple of dozen wholesome volunteers.

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