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Long-term follow-up of patients who received imatinib in the treatment of CML and achieved a complete cytogenic response 2 years after the start of treatment demonstrated that their survival was not statistically significantly different from that of the general population.

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He also developed tools to detect the activity of tyrosine kinases, an accomplishment that proved crucial to the identification of Gleevec.

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Imatinib is used to treat certain types of leukemia (cancer that begins in the white blood cells) and other cancers of the blood cells.

Conditioning regimens can continue as long as the patient is healthy enough to sustain damage by cytotoxic treatments.

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If the transplant can be done while imatinib or dasatinib is working, then the long-term results are better.

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Some of the newly discovered mutations in cancer were truly unexpected: it turned out the genes did not control growth directly, but affected the metabolism of nutrients or chemical modifications of DNA.

STI stands for Signal Transduction Inhibitor and represents the action of the drug to inhibit enzymes called tyrosine kinase inhibitors.

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Because of this, once a biopsy is done to confirm the tumor is a GIST, treatment with imatinib is usually started.

Generally this is achieved through the use of reverse transcription of the RNA followed by polymerase chain reaction.

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Tests which uncover minimal residual disease (one cancerous cell in a population of one million normal cells) are helpful for directing treatment and preventing relapse.

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Female patients of reproductive potential must agree to employ an effective barrier method of birth control throughout the study and for up to 7 days following discontinuation of study drug.

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Although treatment with a TKI can work well for accelerated phase CML, it is less likely to work as well as it does for chronic phase CML.

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This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition.

This medicine makes him very sick and the doctor said there is no other option and he must continue to take medications for the rest of his existance to keep his cells from producing the mutated monocyte blood cells assosciated with CML.

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Half the women with known pregnancy outcomes after imatinib exposure had normal deliveries, However, a dozen pregnancies were associated with severe fetal abnormalities, some similar to malformations in animals during imatinib's development.

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