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Which drug must always be given in combination with levodopa and carbidopa to treat dementia? The drug levodopa is synthesized in the brain into dopamine. It is the most important first-line drug for the management of Parkinson's. Levodopa is almost always given in combination with the drug carbidopa, which prevents the nausea that can be caused by levodopa alone. Carbidopa is also a levodopa enhancer.